中文名称福沙吡坦二甲葡胺

中文同义词福沙吡坦二甲葡胺及全套杂质;福沙吡坦二甲葡胺(MK-0517);福沙匹坦二葡甲胺;福沙匹坦(API);福沙匹坦二甲葡胺;1-脱氧-1-(甲基氨基)-D-葡萄糖醇[3-[[(2R,3S)-2-[(1R)-1-[3,5-双(三氟甲基)苯基]乙氧基]-3-(4-氟苯基)-4-吗啉基]甲基]-2,5-二氢-5-氧代-1H-1,2,4-三唑-1-基]膦酸盐;福沙吡坦二甲葡胺;福沙匹坦二甲葡胺

英文名称Fosaprepitantdimeglumine

英文同义词Phosphonicacid,(3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)-,compd.with1-deoxy-1-(methylamino)-D-glucitol(1:2);Unii-D35fm8T64x;[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate1-Deoxy-1-(MethylaMino)-D-glucitol;1-Deoxy-1-(MethylaMino)-D-glucitol[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate;1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL[[(2R,3S]-2-[(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PHENYL]ETHOXY]-(4-FLUOROPHENYL);3-[2(R)-[1(R)-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)Morpholin-4-ylMethyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-phosphinicacidbis(N-Methyl-D-glucaMine)salt;FosaprepitantdiMegluMinesalt;Fosaprepitantdimeglumine

CAS号265121-04-8

分子式C30H39F7N5O11P

分子量809.63

福沙吡坦二甲葡胺性质

储存条件Sealedindry,Storeinfreezer,under-20°C

溶解度DMSO中≥50.24mg/mL；不溶于乙醇；超声检测水中≥13.16mg/mL

酸度系数(pKa)FosaprepitantdimegluminehasfourfunctionalgroupswhichhavepKavaluesof3.05±0.03,4.92±0.02,9.67±0.01and10.59±0.03.Thepkavalueof3.05correspondstothemorpholiniumgroup,thepkaof4.92correspondstothemonophosphonategroup,thepkaof9.67correspondstothemegluminecounterion,andthepkaof10.59correspondstothetriazolinoneNHgroup.

形态粉末

颜色白色至米白色

旋光度(OpticalRotation)[α]/D+27to+34°,c=0.5inmethanol

福沙吡坦二甲葡胺 用途与合成方法

福沙吡坦二甲葡胺 价格

福沙吡坦二甲葡胺 上下游产品信息